Opti-Est Cream | BiEst 5.0

Ultra-pure bio-identical estrogen cream (E3 + E2) • ~60 pumps

Practitioner-grade hormone support for perimenopause & menopause.
Each metered pump delivers 5 mg bio-identical estrogen (approximately 4 mg Estriol (E3) + 1 mg Estradiol (E2)) in a luxe, fast-absorbing base with MSM, aloe, coconut & olive oils, shea butter, sunflower lecithin for glide and skin barrier love.

  • Estriol (E3) is the most gentle estrogen; topical use can help dryness, skin texture, and urogenital comfort.*
  • Estradiol (E2) is the most potent estrogen; a small dose helps hot flashes, sleep, and mood stabilization.*
  • The 4:1 E3:E2 balance offers a softer physiologic nudge while the silky base ingredients enhance dermal absorption.

GMP compliant • FDA-inspected facility • Quality tested

  • ~60 metered pumps per 3 oz bottle

$59.99 or subscribe to save up to 20%

Availability: 6 in stock (can be backordered)

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. OptiBlissâ„¢ supplements are not a substitute for medical care. Consult your healthcare provider before use, especially if you are pregnant, nursing, taking medication, or have a medical condition.

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Benefits

Women in peri- to post-menopause looking for a gentle, topical E3-forward (estriol-dominant) option with a touch of E2 for symptom relief—guided by a practitioner.

  • Gentle, balanced estrogen support – A Bi-Est blend (estriol + estradiol) designed to provide a smooth, natural-feeling option for women seeking hormone balance with practitioner guidance.*
  • Steady, skin-based delivery – Transdermal cream allows gradual absorption for consistent day-to-day support—no capsules to swallow.*
  • Skin-loving base – Aloe, coconut & olive oils, shea butter, and MSM help the cream spread easily and feel silky—no sticky residue.
  • Absorption focused – MSM and sunflower lecithin are included to support dermal uptake and even delivery across application sites.*
  • Customize with your provider – Airless pump gives predictable, meter-style dosing so you and your practitioner can fine-tune your amount.
  • Fragrance-free, dye-free – Made without parabens or soy; preserved with a gentle botanical/essential-oil system (rosemary, star anise, cinnamon).

Purified water, vegetable glycerin, aloe vera leaf gel, caprylic/capric triglyceride, stearic acid, micronized estriol USP, micronized estradiol USP, olive oil, coconut oil, shea butter, sunflower lecithin, MSM (methylsulfonylmethane), stearyl alcohol, isopropyl palmitate, allantoin, carbomer, sodium bicarbonate, and a proprietary blend of essential oils & herbs (rosemary, star anise, cinnamon) as natural preservatives, plus wildcrafted acacia gum.

  • Free of parabens & phthalates
  • No artificial colors
  • Apply ½–1 full pump daily, rotating sites: chest, inner arms, inner forearms, thighs, and wrists—or as directed by your healthcare professional.
  • For best absorption, apply to clean, dry skin. Allow to dry before dressing.
  • Utilize applicator and wash hands after applying
  • External cosmetic use only.
  • 💡 Tip: Many of our clients start with ½ pump and titrate based on symptoms & practitioner guidance.
  • How many pumps per bottle?
    ~60 metered pumps (3 oz / 85 g).
  • Can I combine with progesterone or DHEA?
    Often yes—coordinate timing & sites with your practitioner.
  • Where should I NOT apply?
    Avoid mucous membranes, broken skin, and the face unless instructed by your clinician.
  • How soon will I notice effects?
    Some notice changes in 2–3 weeks; full equilibrium may take 6–8 weeks under guided dosing.
Cautions
  • For external cosmetic use only.
  • Discontinue if irritation or redness develops; consult your physician.
  • Do not use if pregnant, nursing, or trying to conceive.
  • Consult your practitioner if you have a medical condition or take medications.
  • Keep out of reach of children. Store in a cool, dry place.

Provider Approved

3rd Party Tested & Verified

Powerful & Pure Formulations

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